Human capital, culture and the onset of the demographic transition

This paper uses estimates of the dates at which different countries have experienced their demographic transitions to examine the main historical determinants of these transitions. We first show that genetic distance to the United Kingdom, a measure of cultural relatedness used in Spolaore and Wacziarg (2009), is positively associated with the onset of the demographic transition, implying that countries that have a larger genetic distance from the UK tend to experience later transitions. We then unveil a plausible mechanism that can rationalize this result. We show that genetic distance to the UK is negatively related to a country's initial human capital, measured as its schooling level in 1870. One interpretation of this finding is that a larger genetic distance is associated with higher barriers to technological diffusion and hence a lower demand for human capital. This low demand for human capital then delays the demographic transition by providing less incentives for households to switch from quantity to quality of children. Instrumenting initial human capital using genetic distance to the UK and alternative measures of adherence to Protestantism, we confirm the causal link between human capital and the onset of the demographic transition. Further, we show that the impact of cultural relatedness to the UK can be mainly attributed to its effect on educational levels

Integrating formal reasoning into component-based approach to reconfigurable distributed systems

Distributed computing is becoming ubiquitous in recent years in many areas, especially the scientific and industrial ones, where the processing power - even that of supercomputers - never seems to be enough. Grid systems were born out of necessity, and had to grow quickly to meet requirements which evolved over time, becoming today’s complex systems. Even the simplest distributed system nowadays is expected to have some basic functionalities, such as resources and execution management, security and optimization features, data control, etc. The complexity of Grid applications is also accentuated by their distributed nature, making them some of the most elaborate systems to date. It is often too easy that these intricate systems happen to fall in some kind of failure, it being a software bug, or plain simple human error; and if such a failure occurs, it is not always the case that the system can recover from it, possibly meaning hours of wasted computational power. In this thesis, some of the problems which are at the core of the development and mainte- nance of Grid software applications are addressed by introducing novel and solid approaches to their solution. The difficulty of Grid systems to deal with unforeseen and unexpected cir- cumstances resulting from dynamic reconfiguration can be identified. Such problems are often related to the fact that Grid applications are large, distributed and prone to resource failures. This research has produced a methodology for the solution of this problem by analysing the structure of distributed systems and their reliance on the environment which they sit upon, often overlooked when dealing with these types of scenarios. It is concluded that the way that Grid applications interact with the infrastructure is not sufficiently addressed and a novel approach is developed in which formal verification methods are integrated with distributed applications development and deployment in a way that includes the environment. This approach allows for reconfiguration scenarios in distributed applications to proceed in a safe and controlled way, as demonstrated by the development of a prototype application

Tree Level Unitarity Bounds for the Minimal B-L Model

We have derived the unitarity bounds in the high energy limit for the minimal B-L extension of the Standard Model by analysing the full class of Higgs and would-be Goldstone boson two-to-two scatterings at tree level. Moreover, we have investigated how these limits could vary at some lower critical value of the energy.Comment: 20 pages, 4 figures, 2 tables; 1d figure modified, typos corrected, bibliography augmented; published in PRD after minor adjustmen

The Z' boson of the minimal B-L model at future Linear Colliders in e+e- --> mu+mu-

We study the capabilities of future electron-positron Linear Colliders, with centre-of-mass energy at the TeV scale, in accessing the parameter space of a $Z'$ boson within the minimal $B-L$ model. We carry out a detailed comparison between the discovery regions mapped over a two-dimensional configuration space ($Z'$ mass and coupling) at the Large Hadron Collider and possible future Linear Colliders for the case of di-muon production. As known in the literature for other $Z'$ models, we confirm that leptonic machines, as compared to the CERN hadronic accelerator, display an additional potential in discovering a $Z'$ boson as well as in allowing one to study its properties at a level of precision well beyond that of any of the existing colliders.Comment: 5 pages, proceeding of LC09 (Perugia), published by the Italian Physical Society in the Nuovo Cimento C (Colloquia

Current medical treatment of estrogen receptor-positive breast cancer

Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have been demonstrated many years ago, and currently ET consist of (i) ovarian function suppression (OFS), usually obtained using gonadotropin-releasing hormone agonists (GnRHa), (ii) selective estrogen receptor modulators or down-regulators (SERMs or SERDs), (iii) aromatase inhibitors (AIs), or a combination of two or more drugs. For patients aged less than 50 years and ER+ BC, there is no conclusive evidence that the combination of OFS and SERMs (i.e. tamoxifen) or chemotherapy is superior to OFS alone. Tamoxifen users exhibit a reduced risk of BC, both invasive and in situ, especially during the first 5 years of therapy, and extending the treatment to 10 years further reduced the risk of recurrences. SERDs (i.e. fulvestrant) are especially useful in the neoadjuvant treatment of advanced BC, alone or in combination with either cytotoxic agents or AIs. There are two types of AIs: type I are permanent steroidal inhibitors of aromatase, while type II are reversible nonsteroidal inhibitors. Several studies demonstrated the superiority of the third-generation AIs (i.e. anastrozole and letrozole) compared with tamoxifen, and adjuvant therapy with AIs reduces the recurrence risk especially in patients with advanced BC. Unfortunately, some cancers are or became ET-resistant, and thus other drugs have been suggested in combination with SERMs or AIs, including cyclin-dependent kinase 4/6 inhibitors (palbociclib) and mammalian target of rapamycin (mTOR) inhibitors, such as everolimus. Further studies are required to confirm their real usefulness

Arrhythmogenic right ventricular cardiomyopathy associated with severe left ventricular involvement in a cat.

An 8-year-old, 4 kg, intact female, domestic shorthaired cat was referred for tachypnea and pleural effusion. A 24-h Holter recording showed numerous polymorphic ventricular premature complexes with left and right bundle branch block morphology. Echocardiographic examination revealed right atrial and ventricular dilation. The right ventricular free wall was thin and aneurysmal. The cat died 10 days after initiation of antiarrhythmic therapy. Gross and histopathological findings were consistent with arrhythmogenic right ventricular cardiomyopathy (ARVC) associated with severe left ventricular involvement

Temporal specification and deductive verification of a distributed component model and its environment

In this paper we investigate the formalisation of distributed and long-running stateful systems using our normative temporal specification framework. We analyse aspects of a component-oriented Grid system, and the benefits of having a logic-based tool to perform automated and safe dynamic reconfiguration of its components. We describe which parts of this Grid system are involved in the reconfiguration process and detail the translation procedure into a state-based formal specification. Subsequently, we apply deductive verification to test whether dynamic reconfiguration can be performed. Finally, we analyse the procedure required to update our model for reconfiguration and justify the validity and the advantages of our methodology

Photon and Pomeron -- induced production of Dijets in pppp, pApA and AAAA collisions

In this paper we present a detailed comparison of the dijet production by photon -- photon, photon -- pomeron and pomeron -- pomeron interactions in $pp$, $pA$ and ${\rm AA}$ collisions at the LHC energy. The transverse momentum, pseudo -- rapidity and angular dependencies of the cross sections are calculated at LHC energy using the Forward Physics Monte Carlo (FPMC), which allows to obtain realistic predictions for the dijet production with two leading intact hadrons. We obtain that \gamma \pom channel is dominant at forward rapidities in $pp$ collisions and in the full kinematical range in the nuclear collisions of heavy nuclei. Our results indicate that the analysis of dijet production at the LHC can be useful to test the Resolved Pomeron model as well as to constrain the magnitude of the absorption effects.Comment: 11 pages, 6 figures, 1 table. Improved and enlarged version published in European Physical Journal

Inclusive hadron and photon production at LHC in dipole momentum space

Using a momentum space model for the dipole scattering amplitude we present an analysis of the saturation effects at LHC energies, describing the data on proton-proton and proton-lead collisions. The model is based on the asymptotic solutions of the Balitsky-Kovchegov equation, being ideal in the saturation domain where the target wave function has a high occupation number. We also make predictions for the nuclear modification ratios on charged hadron and prompt photon production in the forward region, where the high parton density effects are important.Comment: New section added and typos corrected. To be published in PR